產(chǎn)品詳情

  • 產(chǎn)品名稱：rMaurotoxin(MTX)

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  • 產(chǎn)品廠商：BioLeaf
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rMaurotoxin(MTX)
詳情介紹：
Sequence VSCTGSKDCY APCRKQTGCP NAKCINKSCK CYGC.
Specificity Maurotoxin activity was extensively assayed on a large array of K+ channels, including KCa (KCa1.1, KCa2.1, KCa2.2, KCa2.2, KCa3.1), KCNA (KCNA1, KCNA2 and KCNA3) and Shaker B K+ currents and seems to be very potent blocker of either KCa3.1 and KCNA2 channels3.
Characteristics Source: Scorpio maurus palmatus (Chactoid scorpion).
Molecular formula: C145H232N46O46S8.
Disulfide bonds between Cys3-Cys24, Cys9-Cys29, Cys13-Cys29, and Cys31-Cys34.
Purity > 98 %
Molecular Weight 3613
Application Notes 1-200 nM
Comment

K+ channel toxin -KTx 6.2
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.384 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Rodríguez de la Vega, Possani: "Current views on scorpion toxins specific for K+-channels." in: Toxicon : official journal of the International Society on Toxinology, Vol. 43, Issue 8, pp. 865-75, 2004 (PubMed).

Visan, Sabatier, Grissmer: "Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels (hIKCa1)." in: Toxicon : official journal of the International Society on Toxinology, Vol. 43, Issue 8, pp. 973-80, 2004 (PubMed).

Castle, London, Creech, Fajloun, Stocker, Sabatier: "Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels." in: Molecular pharmacology, Vol. 63, Issue 2, pp. 409-18, 2003 (PubMed).

Carlier, Avdonin, Geib, Fajloun, Kharrat, Rochat, Sabatier, Hoshi, De Waard: "Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels." in: The journal of peptide research : official journal of the American Peptide Society, Vol. 55, Issue 6, pp. 419-27, 2000 (PubMed).

Kharrat, Mabrouk, Crest, Darbon, Oughideni, Martin-Eauclaire, Jacquet, el Ayeb, Van Rietschoten, Rochat, Sabatier: "Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels." in: European journal of biochemistry / FEBS, Vol. 242, Issue 3, pp. 491-8, 1997 (PubMed).

Kharrat, Mansuelle, Sampieri, Crest, Oughideni, Van Rietschoten, Martin-Eauclaire, Rochat, El Ayeb: "Maurotoxin, a four disulfide bridge toxin from Scorpio maurus venom: purification, structure and action on potassium channels." in: FEBS letters, Vol. 406, Issue 3, pp. 284-90, 1997 (PubMed).