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Characteristics
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PubChem CID: 54764565
Molecular Formula: C??H??N?
Cell Premeable: Yes URMC-099 is a brain-permeable, mixed lineage kinase (MLK) inhibitor with IC?? values of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. In vitro, URMC-099 treatment reduces inflammatory cytokine production by HIV-1 Tat-exposed microglia and prevents destruction and phagocytosis of cultured neuronal axons by these cells. Smiles: CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6 InChi: InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30) Inchi Key: QKKIWEILHCXECO-UHFFFAOYSA-N
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