產(chǎn)品詳情
                        
      
                        
      
                            
      
                                
                            
      
                            
      
                                
                                
                            
      
                            

                            
      
    
      
    
      
        
      
    
      
            
      

                
      
                    
                    
        
                          
      • 產(chǎn)品名稱：NVP-BHG712
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      • 產(chǎn)品型號：
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      • 產(chǎn)品廠商：Biovision
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      • 產(chǎn)品文檔：
                          
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            簡單介紹：
        
      
        
      
            NVP-BHG712
        
      
    
      

    
      
        
      
            詳情介紹：
        
      
        
      
            
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                        
      
                                                                                    
                                                Purpose
                                            
                                        
                                                                                    
                                            
                                                A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
      
                                                                                    
                                                Characteristics
                                            
                                        
                                                                                    
                                            
                                                Off-white solid 
       Molecular formular: C26H20F3N7O
                                                                                                  		
                                                                            
      
                                                                                                                                                                                                                                                            
      
                                                                                    
                                                Purity
                                            
                                        
                                                                                    
                                            
                                                ≥ 98?% by HPLC
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
      
                                                                                    
                                                Chemical Name
                                            
                                        
                                                                                    
                                            
                                                4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide
                                                                                            
                                                                            
      
                                                                                                                                                                
      
                                                                                    
                                                Formula
                                            
                                        
                                                                                    
                                            
                                                C??H??F?N?O
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
      
                                                                                    
                                                Permeability
                                            
                                        
                                                                                    
                                            
                                                Cell-permeable
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                            
                          
                
      
            
      
                                                                        
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
      
                                                                                    
                                                Molecular Weight
                                            
                                        
                                                                                    
                                            
                                                503.48 g/mol
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
      
                                                                                    
                                                CAS-No
                                            
                                        
                                                                                    
                                            
                                                940310-85-0
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                            
                          
                
      
            
      
                                                            
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                                                                                                                    
      
                                                                                    
                                                Comment
                                            
                                        
                                                                                    
                                            
                                                
      Synonyms: 
       4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide 
      A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis
      
                                                                                                  		
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
      
                                                                                    
                                                Restrictions
                                            
                                        
                                                                                    
                                            
                                                For Research Use only
                                                                                            
                                                                            
      
                                                                                    
                          
                
      
            
      
                                                                                                
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                        
      
                                                                                    
                                                Format
                                            
                                        
                                                                                    
                                            
                                                Solid
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
      
                                                                                    
                                                Handling Advice
                                            
                                        
                                                                                    
                                            
                                                Protect from air and light
                                                                                            
                                                                            
      
                                                                                                                                                                
      
                                                                                    
                                                Storage
                                            
                                        
                                                                                    
                                            
                                                -20 °C
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                            
      
                                                                                    
                                                Expiry Date
                                            
                                        
                                                                                    
                                            
                                                24 months
                                                                                            
                                                                            
      
                                                                                    
                          
                
      
            
      
                                                            
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                        
      
                                                                                    
                                                Supplier Images
                                            
                                        
                                                                                    
                                                
      
                    
      
            
      
                
                                             image for NVP-BHG712 (ABIN1889005)
                        
                                    

                                    
                        NVP-BHG712