產(chǎn)品詳情

  • 產(chǎn)品名稱：TubastatinA

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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TubastatinA
詳情介紹：
Characteristics Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 μM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5 μM with near complete protection at 10 μM.
Purity ≥ 98?% by HPLC
Chemical Name n-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide
Formula C??H??N?O?.HCl
Permeability Cell-permeable
Molecular Weight 371.86 g/mol
CAS-No 1239262-52-2
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for Tubastatin A (ABIN628994) Tubastatin A
Product cited in: Nanduri, Hao, Fitzpatrick, Yao: "Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance." in: The Journal of biological chemistry, Vol. 290, Issue 15, pp. 9455-64, 2015 (PubMed).

Parab, Shetty, Gaonkar, Balasinor, Khole, Parte: "HDAC6 deacetylates alpha tubulin in sperm and modulates sperm motility in Holtzman rat." in: Cell and tissue research, 2014 (PubMed).